Patients with combined exercise and regadenoson stress testing were excluded from analysis. Press question mark to learn the rest of the keyboard shortcuts. If your post contains references to modafinil/armodafinil vendors or sources, please make sure they get removed. Categorical variables were compared using the χ2 test and continuous variables were computed using student t test. CYP450 inducers, such as phenytoin, phenobarbital, or rifampin, as well as smoking have been associated with a shortened caffeine half-life [17–18]. showed that moderate caffeine intake 2 hours prior to regadenoson administration did not affect myocardial blood flow (MBF) and blood pressure response but resulted in a blunted heart rate response [10]. Was it something that really caused your anxiety to spike or did you just get a mild boost in energy, wakefulness and focus? I've done that, but just for a week or two, didn't have any adverse effects. Beta-blockers like propranolol metabolize quickly. [4–6]. Apple cider vinegar with pure lemon juice I think helps. Press J to jump to the feed. Continuous variables are expressed as mean ± SD. A low dosage of beta-blockers (like the 10mg dosage generally prescribed for performance anxiety), will: Leave the system more quickly; Performed the experiments: RK RM AB. The study protocol was approved by the Indiana University institutional review board for research. But, should I also avoid all other caffeine, i.e. I recently had my dose increased (80mg/day - I take it as a migraine preventative) and can barely make it through the day I've been so tired. The project was supported by the Indiana University Health Values Grant, the Indiana University Health–Indiana University School of Medicine Strategic Research Initiative, and the Methodist Research Institute Showalter Grant for Cardiovascular Research. Non-coffee drinkers (group 1) were compared to subjects who had consumed coffee within 12 to 24 hours (group 2) or more than 24 hours (group 3) prior to regadenoson administration. This doc thinks my anxiety is what is causing these spikes, and that propranolol might help with both anxiety and bp. We intended to examine the effect of caffeine consumption and of timing of last dose on hemodynamic effects after regadenoson administration for cardiac stress testing. Non-coffee drinkers tended to be younger (57.2±10.5 vs. 60.9±10.5 years, p = 0.01), more obese (105.7±30.7 vs.97.3±23.5 Kg., p = 0.014), consumed less chocolate (69.9% vs. 80.9%, p = 0.042), had more GERD (41.1% vs. 28.4%, p = 0.039) and were less frequently prescribed antiplatelet medication (37% vs. 52.9%, p = 0.016) as compared to coffee consumers. It has been previously demonstrated that caffeine administered in doses of 200 or 400mg 90 minutes before regadenoson significantly reduces the sensitivity of MPI [11]. Caffeine works by blocking adenosine (an inhibitory neurotransmitter) from binding to adenosine receptors. I'm 36 but have a family history of all sorts of heart disease, so figured better safe than sorry. I don't drink them often, but also don't want to never have them again. Then I could take Propranolol, a beta blocker for anxiety instead of Klonopin. broad scope, and wide readership – a perfect fit for your research every time. Multivariable linear regression with change in systolic blood pressure (SBP), HR, and percent maximal predicted heart rate achieved at peak exercise as outcome variables was performed for non-coffee drinkers, subjects exposed to coffee 12 to 24 hours and more than 24 hours before regadenoson administration. No, Is the Subject Area "Hemodynamics" applicable to this article? Unless you are a doctor (submission for verification is greatly encouraged) advocating any medication or medical course of actions are discouraged. Subjects referred for regadenoson stress testing were enrolled. I am a bot, and this action was performed automatically. It is therefore possible that based on variations in caffeine metabolism, exposure to caffeine between 12–24 hours before regadenoson could also reduce the sensitivity of regadenoson MPI. Caffeine exposure within 12–24 hours prior to regadenoson MPI seems to attenuate the hemodynamic effect of regadenoson as indicated by blunting of heart rate and systolic blood pressure rise. Can confirm it does help with my anxiety-related BP spikes. There is more than one kind of beta blocker out there. Modafinil allows me to think clearer and speak more comfortably in social situations - however I would like to be able to stifle the physical anxiety symptoms that can sometimes occur alongside it. I'm sorry you went through that. Worried about getting a stroke, I went to the doctor's today (a different person), who recommended 20mg of propranolol a day. A2A receptor agonists have been shown to modulate the response to beta adrenergic stimulation by attenuating the effect of A1 receptor and increasing contractility directly [31]. This comment is automatically added to all posts for visibility. Vasodilator stress testing accounts for up to 45% of MPI studies [2]. Adjustment for known confounders was based on clinical variables known to affect caffeine metabolism, as well as clinical variables with p<0.1 in univariable analysis and if adjustment for the variables resulted in at least a 10% change in the estimate of the overall association. I never drink coffee or energy drinks. Press question mark to learn the rest of the keyboard shortcuts. In the coronary circulation, there is a high reserve for A2A receptor mediated coronary vasodilation with 25% receptor occupancy by regadenoson translating into 90% maximal vasodilation [10,28]. I had to stop drinking coffee personally because it was too tempting to take a higher dose of klonopin before work, counting on the coffee I would drink once I got there to balance out the heavier dose, trying to reach the perfect combination of focused, motivated and relaxed. Information on amount, frequency, and last exposure to caffeine, chocolate, and caffeinated soft drinks were collected prospectively prior to performance of cardiac stress test. The site may not work properly if you don't, If you do not update your browser, we suggest you visit, Press J to jump to the feed. 20mg, twice daily. I have that all-day-long panic from Modafinil alone on occasions, and I was hoping the Propranolol could counteract it. It generally depends on how much coffee and how much you need that kpin. In contrast, in the peripheral vasculature, A2A receptor reserve may be lower, thus possibly explaining a blunted increase in heart rate in response to regadenoson in subjects exposed to caffeine [10].
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